Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence |
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| Authors: | Nöth Julica Frankowski Kevin J Neuenswander Benjamin Aubé Jeffrey Reiser Oliver |
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| Institution: | Institut für Organische Chemie, Universit?t Regensburg, Universit?tsstrasse 31, 93053 Regensburg, Germany. |
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| Abstract: | A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library. |
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