| 取代邻苯二酚Mannich反应研究I: |
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| 引用本文： | 梁诚一,薛芬.取代邻苯二酚Mannich反应研究I:[J].化学学报,1987,45(1):99-102. |
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| 作者姓名： | 梁诚一 薛芬 |
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| 作者单位： | 上海医科大学药学院有机化学教研室 |
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| 摘 要： | 把3-N,N-双(羧甲基)氨甲基]邻苯二酚和哌啶,吡咯,二乙胺,吗啉和哌嗪在加热可得到相应的5-取位Mannich碱.研究了Mannich反应的机理,理解了这一Mannich反应的定位是由于反应物的分子内氢键.但是在与亚胺基二乙酸反应时或3-吗啉甲基邻苯二酚与吗啉反应,得到正常的6-取代Mannich碱.
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| 关 键 词： | 哌啶P 反应机理 红外分光光度法 核磁共振谱法 甲醛 氢键 苯二酚P 乙酸P 曼尼希反应 吗啉 |
Studies on the mannich reaction of substituted catechol I: |
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| LIANG CHENGYI,XUE FEN.Studies on the mannich reaction of substituted catechol I:[J].Acta Chimica Sinica,1987,45(1):99-102. |
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| Authors: | LIANG CHENGYI XUE FEN |
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| Abstract: | Mannich reaction of 3-N,N-bis(carboxymethyl)aminomethyl]catechol (I) with piperidine, pyrroline, diethylamine, morpholine and piperazine gave the corresponding 5-substituted Mannich bases. The orientation of this Mannich reaction was explained through the intramol. hydrogen bonding of the starting material. However, the reaction of I with iminodiacetic acid or 3-(morpholinomethyl)catechol with morpholine gave the normal 6-substituted Mannich bases. |
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| Keywords: | PIPERIDINE P REACTION MECHANISM INFRARED SPECTROPHOTOMETRY NMR SPECTROMETRY FORMALDEHYDE HYDROGEN BONDS BENZENEDIOL P ACETIC ACID P MANNICH REACTION MORPHOLINE |
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