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Funnels in energy landscapes |
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| Authors: | K Klemm C Flamm P F Stadler |
| Institution: | 1. Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, H?rtelstrasse 16-18, 04107, Leipzig, Germany 2. Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria 3. RNomics Group, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany 4. Santa Fe Institute, Santa Fe, New Mexico, USA |
| Abstract: | Local minima and the saddle points separating them in the energy landscape are known to dominate the dynamics of biopolymer folding. Here we introduce a notion of a “folding funnel” that is concisely defined in terms of energy minima and saddle points, while at the same time conforming to a notion of a “folding funnel” as it is discussed in the protein folding literature. |
| Keywords: | PACS" target="_blank">PACS 87 10 +e General theory and mathematical aspects 87 15 Cc Folding and sequence analysis 89 75 Fb Structures and organization in complex systems |
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