| 超顺磁中空碳胶囊的合成及其载药性能研究 |
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| 引用本文： | 郝凌云,张文保,蒋雪月,王洪涛,龚兴龙,江万权.超顺磁中空碳胶囊的合成及其载药性能研究[J].阜阳师范学院学报(自然科学版),2009,26(2):1-5. |
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| 作者姓名： | 郝凌云 张文保 蒋雪月 王洪涛 龚兴龙 江万权 |
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| 作者单位： | 1. 阜阳师范学院,化学化工学院,安徽,阜阳,236041
2. 中国科学院,材料力学行为和设计重点实验室,安徽,合肥,230027 |
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| 基金项目： | 国家自然科学基金，安徽省2008年度高层次人才引进及创新创业资助项目 |
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| 摘 要： | 利用聚苯乙烯-丙烯酸（PSA）共聚物胶粒为模板，采用控制沉降和原位聚合的方法首先合成PSA@Fe2O4／聚砒咯（PPy）复合核壳粒子；将去核后得到的Fe3O4／PPy空心胶囊进一步热解炭化，制备了单分散Fe3O4／Carbon空心胶囊．样品物相及结构经X射线衍射仪（XRD）、透射电子显微镜（TEM）和扫描电子显微镜（SEM）表征．超导量子干涉仪（SQUID）测定结果显示，碳胶囊样品呈超顺磁性．N2气吸附测试结果显示磁性碳胶囊的比表面积BET为98m^2／g．以Fe3O4／Carbon磁性空心胶囊对抗癌药物阿霉素进行负载后，体外模拟释放实验结果显示胶囊具有良好的药物缓释性能．
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| 关 键 词： | 碳胶囊 超顺磁 药物载体 |
Fabrication of ferromagnetic carbon hollow capsules for drug carriers |
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| HAO Ling-yun,ZHANG Wen-bao,JIANG Xue-yue,WANG Hong-tao,GONG Xing-long,JIANG Wan-quan.Fabrication of ferromagnetic carbon hollow capsules for drug carriers[J].Journal of Fuyang Teachers College:Natural Science,2009,26(2):1-5. |
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| Authors: | HAO Ling-yun ZHANG Wen-bao JIANG Xue-yue WANG Hong-tao GONG Xing-long JIANG Wan-quan |
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| Institution: | HAO Ling-yun 1,ZHANG Wen-bao1,JIANG Xue-yue1,WANG Hong-tao1,GONG Xing-long2,JIANG Wan-quan2 (1.School of Chemistry and Chemical Engineering,Fuyang Teachers College,Fuyang Anhui,236041,China 2.CAS Key Laboratory of Mechanical Behavior and Design of Materials,USTC,Hefei Anhui 230027,China) |
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| Abstract: | A versatile approach is reported for fabrication of ferromagnetic carbon hollow capsules.PSA@Fe3O4/polypyrrole(PPy) core-shell latex was firstly fabricated then transformed to Fe3O4/PPy hollow capsule after removed core.Carbon hollow capsules were obtained via carbonization-reduction process from Fe3O4/PPy capsules heated at 550oC.Their microstructures were observed by a high resolution transmission electron microscope(HRTEM) and the magnetism was characterized with a superconducting quantum interference de... |
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| Keywords: | carbon hollow capsules ferromagnetic property drug carrier |
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