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An improved synthesis of 3,5-disubstituted isoxazoles and pyrazoles from C(α),O-dilithiooximes and C(α),N-dilithiophenylhydrazones |
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| Authors: | Tammy D. Fulmer Lisette P. Dasher Bonni L. Bobb Jana D. Wilson Kimberly L. Sides Charles F. Beam |
| Abstract: | C(α),O-Dilithiooximes and C(α),N-dilithiophenylhydrazones were prepared using an excess of lithium diisopropylamide (1:3). Condensation with esters followed by acid cyclization gave isoxazoles and pyrazoles. |
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