Syntheses with nitriles. 60. Preparation of 4-amino-5-cyano-6-phenylpyrimidines from 2-amino-1,1-dicyano-2-phenylethene |
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Authors: | Martin Mittelbach Hans Junek |
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Abstract: | The reaction of 2-amino-1,1-dicyanobut-1-ene and 2-amino-1,1-dicyano-2-phenylethene, respectively, with N,N-dimethylformamide dimethylacetal provided the corresponding (N,N-dimethylaminomethylene)amino derivatives. 2-[(N,N-Dimethylaminomethylene)amino]-1,1-dicyano-2-phenylethene was converted into 4-amino-5-cyano-6-phenylpyrimidines by treatment with primary aliphatic and aromatic amines. The structure of the reaction products was confirmed by 13C nmr spectroscopy. |
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