The chameleon-like behaviour of 3-amino-1,2,4-triazole in the Biginelli reaction: unexpected formation of a novel spiroheterocyclic system |
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| Authors: | Jan Světlí k,Viktor Kettmann |
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| Affiliation: | Department of Pharmaceutical Analysis and Nuclear Pharmacy, Comenius University, Odbojarov 10, SK-832 32 Bratislava, Slovak Republic |
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| Abstract: | A novel Biginelli-like assembly of 3-amino-1,2,4-triazole with methyl acetoacetate and salicylaldehyde has been developed to enable easy access to spiro{[1]benzopyran-2,7′-[1,2,4]triazolo[1,5-a]pyrimidine} compounds as representatives of a new class of spiro-fused heterocycles. A three-component condensation mechanism is proposed and discussed. |
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| Keywords: | Biginelli reaction Oxaspiro-heterocyclic system Salicylaldehyde 3-Amino-1,2,4-triazole |
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