Encapsulation of nanoparticles using linear–dendritic macromolecules |
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Authors: | H Namazi M Adeli Z Zarnegar S Jafari A Dadkhah A Shukla |
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Institution: | 1.Lab of Dendrimers and Biopolymers, Faculty of Chemistry,University of Tabriz,Tabriz,Iran;2.Department of Chemistry, Faculty of Science,Lorestan University,Khoramabad,Iran;3.Organische Chemie,Universit?t Dortmund,Dortmund,Germany |
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Abstract: | Benzyl alcohol and Rose Bengal were loaded and entrapped using linear–dendritic macromolecules by two procedures. In the first
procedure, benzyl alcohol was attached to the end functional groups of linear–dendritic macromolecules by ester bonds to afford
linear–dendritic–host conjugates. In the second procedure, entrapment was based on physical interactions between Rose Bengal
and linear–dendritic macromolecules; this procedure is known as complexation method. Loading and binding capacity of different
linear–dendritic macromolecules was investigated using 1H nuclear magnetic resonance (NMR) and UV spectroscopy methods. It was found the loading or binding capacity of linear–dendritic
macromolecules depends on their generation, so that higher generations have higher loading or binding capacity. Diameter of
nanocarriers was investigated using dynamic light scattering (DLS) experiments, and it was between 16 and 50 nm for different
nanocarriers. Release of guest molecules from nanocarriers was evaluated at pH 1, 7.4, and 10.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | Nanocarriers Encapsulation Dendrimer Nanoparticles Linear– dendritic |
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