Absolute stereochemistry of amphidinolide C: synthesis of C-1-C-10 and C-17-C-29 segments |
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| Authors: | Takaaki KubotaMasashi Tsuda Jun'ichi Kobayashi |
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| Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan |
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| Abstract: | Two of each diastereomers of the C-1-C-10 and C-17-C-29 segments of amphidinolide C (1) were synthesized. Comparing the 1H NMR chemical shifts of its MTPA esters with those of linear methyl ester of 1, the absolute configurations at C-7, C-8, C-20, C-23, and C-24 in amphidinolide C (1) were confirmed to be all R. |
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| Keywords: | amphidinolide C α-methoxy-α-trifluoromethylphenylacetyl acetonide |
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