Synthesis and glycosidase inhibitory activity of pseudo-di-(or tri-)saccharides |
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| Authors: | Isabelle McCortMichèle Sanière Yves Le Merrer |
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| Institution: | Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université René Descartes, UMR 8601, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France |
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| Abstract: | The synthesis of pseudo-di-(or tri-)saccharides with a d-mannoazepane or a l-gulopiperidine skeleton either N-linked to a d-gluco-C-furanoside or to d-mannitol, and evaluation of their inhibitory activities against α- or β-d-glucosidase, α-d-mannosidase and α-l-fucosidase are described. |
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| Keywords: | pseudo-saccharides glycosidases mannitol azepane piperidine C-furanoside |
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