An improved large scale synthesis of 1,4-anhydro-4-thio-d-ribitol |
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| Authors: | Noriaki Minakawa Yuka KatoKoichi Uetake Daisuke KagaAkira Matsuda |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan |
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| Abstract: | An improved large scale synthesis of 1,4-anhydro-4-thio-d-ribitol (4) from d-ribose has been accomplished by combining the O-allyl and O-p-methoxybenzyl protecting groups. Compound 4 was obtained in 31% yield in eight steps with three chromatographic separations. |
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| Keywords: | thiosugars sulfides protecting groups |
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