Voltammetric behavior of methaqualone and its determination by single-sweep oscillopolarography

A well derivative reduction wave of methaqualonc (MTQ) was obtained in 0.033 mol dm⁻³ B-R (pH 3.76) buffer solution by single-sweep oscillopolarography. The peak potential is −1.36 V (vs. saturated calomel reference electrode, SCE). The peak current is proportional to the concentration of methaqualone over the range of 7.0×10⁻⁸-9.0×10⁻⁶ mol dm⁻³. The method has been successfully applied to the determination of methaqualone in tablets. The wave is believed to result from irreversible adsorption through studies of its electrochemical behavior and reaction mechanism.