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Double thioalkylation/arylation of nitroarenes with the reduction of nitro- to amino group
Authors:Zbigniew Wróbel
Institution:Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, PL-01-224 Warsaw, Poland
Abstract:Some active bicyclic nitroarenes readily react with an excess of alkyl/arylthiols in the presence of DBU and bis-trimethylsilylacetamide (BSA) in DMF solution, to give dithioalkyl/aryl substituted anilines in moderate to good yields via displacement of ortho- and para-hydrogen atoms with simultaneous reduction of the nitro- to amino-group.
Keywords:bicyclic aromatic compounds  thiols  substitution  reduction  amines
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