|
|||||
|
|
Synthesis and properties of polyaromatic dendrimers possessing a repetitive amide-ester coupling sequence |
|
| Authors: | Barbara RomagnoliPeter R. Ashton Laurence M. HarwoodDouglas Philp David W. Price Melanja H. SmithWayne Hayes |
| Affiliation: | a School of Chemistry, The University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK b School of Chemical Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK c Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, UK |
| Abstract: | A series of novel polyaromatic dendrimers that feature tris-(2-ethylamino)amine as the central core unit has been synthesized up to the third generation by employing a convergent growth strategy. The building blocks 1,3-diamino-2-hydroxypropane and 4-carboxybenzaldehyde were used for dendron construction, a process that involved the cyclic repetition of esterification, oxidation and selective amidation steps. Molecular modelling of this class of dendrimers has been used to predict potential solution state conformations employing molecular mechanics and molecular dynamic simulations. In addition, the results of preliminary metal binding studies using the first generation dendritic system are also outlined. |
| Keywords: | dendrimer polyamide polyester convergent synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |