Conditions for deuterium exchange mediated by iridium complexes formed in situ |
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| Authors: | Paul WC CrossGeorge J Ellames Jennifer S GibsonJohn M Herbert William J KerrAlan H McNeill Trevor W Mathers |
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| Institution: | a Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK
b Department of Isotope Chemistry and Metabolite Synthesis, Sanofi-Synthélabo, Willowburn Avenue Alnwick, Northumberland NE66 2JH, UK |
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| Abstract: | A series of iridium-based complexes formed in situ, containing pyridine, phosphines, triphenylarsine, triphenylstibine, and triphenylamine as ligands, has been screened for ability to mediate ortho-exchange of hydrogen in a series of model substrates. Improved incorporation into a number of substrate classes has been achieved. The electronic properties and number of ligands at the metal centre are instrumental in determining which catalysts are best suited to exchange in any given substrate. |
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| Keywords: | iridium complexes deuterium exchange isotope exchange |
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