Novel synthesis of indolizidines and quinolizidines |
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| Authors: | Kourosch Abbaspour TehraniMatthias D'hooghe Norbert De Kimpe |
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| Institution: | Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium |
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| Abstract: | A very short synthesis of indolizidines, quinolizidines and some higher homologues was developed by alkylation of 2-methyl-1-pyrroline or 6-methyl-2,3,4,5-tetrahydropyridine with 1,3- or 1,4-dihaloalkanes, followed by reduction of the intermediate iminium salts, resulting in the desired 1-azabicyclom.n.0]alkanes in good yields. |
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| Keywords: | iminium salts reduction indolizidines |
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