An efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water: effect of additive on radical reaction in water |
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Authors: | Hisanori NambuGopinathan Anilkumar Masato MatsugiYasuyuki Kita |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan |
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Abstract: | The combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier, 1-ethylpiperidine hypophosphite (EPHP) and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. The effect of additives and surfactant in the radical cyclization reaction in water was also investigated. |
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Keywords: | cetyltrimethylammonium bromide C-C bond radical reactions |
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