An efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water: effect of additive on radical reaction in water

The combination of the water-soluble radical initiator, 2,2′-azobis2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier, 1-ethylpiperidine hypophosphite (EPHP) and surfactant, cetyltrimethylammonium bromide (CTAB), was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. The effect of additives and surfactant in the radical cyclization reaction in water was also investigated.