Chemo- and regioselectivity in the reactions between highly electrophilic fluorine containing dicarbonyl compounds and amines. Improved synthesis of the corresponding imines/enamines |
| |
| Authors: | Hironari OhkuraDmitrii O. Berbasov Vadim A. Soloshonok |
| |
| Affiliation: | Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, OK 73019, USA |
| |
| Abstract: | Chemo- and regioselectivity in the reactions between highly electrophilic fluorine containing dicarbonyl compounds (ethyl 4,4,4-trifluoroacetoacetate, 3,3,3-trifluoropyruvate and 1,1,1,5,5,5-hexafluoropentane-2,4-dione) and various benzylamines were systematically studied. The results obtained lead to the development of a generalized and practical method for large-scale synthesis of the corresponding imines/enamines, useful starting materials for preparation fluorinated amines and amino acid. |
| |
| Keywords: | chemoselectivity regioselectivity nucleophilicity electrophilicity enamines imines fluorine and compounds |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
