Clean and efficient microwave-solvent-free synthesis of 1-(2′,4′-dichlorophenacyl) azoles |
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Authors: | Eduardo R PérezAndré Loupy Marion LiagreAna M de Guzzi Plepis Paulo J Cordeiro |
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Abstract: | Microwave induced N-alkylation of several azoles with 2,2′,4′-trichloroacetophenone (TCA) under solvent-free conditions allowed to obtain the corresponding 1-(2′,4′-dichlorophenacyl) azoles with satisfactory to good selectivities and yields. TGA and DSC measurements were achieved for the synthesized compounds and showed a close relationship between the thermal behavior and the reaction temperature under microwave heating. Non-purely thermal microwave effects were evidenced during the alkylation of pyrazole and 1H-indazole under the selected conditions. |
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Keywords: | azoles N-alkylation microwave irradiation solvent-free fungicides |
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