Cyclization into perhydronaphthalenones using samarium diiodide |
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Authors: | Masakazu SonoSachiko Onishi Motoo Tori |
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Institution: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan |
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Abstract: | Samarium(II) diiodide has been employed to promote the intramolecular cyclization reactions of aldehydes or ketones onto α,β-unsaturated ketones. The cyclization reactions described herein provide a general approach to the syntheses of perhydronaphthalenones with a cis-relationship between the OH at C-5 and the proton or methyl group at C-4a with good diastereoselectivity under mild reaction conditions. |
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Keywords: | samarium diiodide cyclization perhydronaphthalenones |
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