Simple and convenient synthesis of tertiary benzanilides using dichlorotriphenylphosphorane |
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Authors: | Isao Azumaya Takako OkamotoFumiaki Imabeppu Hiroaki Takayanagi |
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Institution: | School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan |
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Abstract: | Various tertiary benzanilide derivatives were effectively synthesized from substituted benzoic acid and N-monoalkylated aniline using dichlorotriphenylphosphorane in chloroform. Yields were generally high, even when an electron-withdrawing group substituted the aromatic ring of aniline, or when an electron-donating group substituted the aromatic ring of benzoic acid. Allyl, Boc, MPM and the Z group were unaffected under these conditions. |
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Keywords: | tertiary amide aromatic amide coupling reagent cyclic amide |
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