Synthesis of dihydrooxazole analogues derived from linezolid |
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| Authors: | Jü rgen EinsiedelChristoph Schoerner,Peter Gmeiner |
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| Affiliation: | a Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany
b Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University, Wasserturmstraße 3, D-91054 Erlangen, Germany |
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| Abstract: | Starting from (S)-serine, the linezolid analogue 3 with dihydrooxazole partial structure was synthesized and pharmacologically investigated. With the help of MEP comparisons structural requirements for antibacterial activity were evaluated. |
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| Keywords: | serine dihydrooxazoles antibiotics |
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