Preparation of 5-diaminomethylenebarbiturates by barbituric acid addition to carbodiimides |
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| Authors: | Branko S Jursic Fred DouelleEdwin D Stevens |
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| Institution: | Department of Chemistry, University of New Orleans, Lakefront, New Orleans, LA 70148, USA |
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| Abstract: | Through NMR spectroscopic monitoring of barbituric acid addition to carbodiimide, a general synthetic procedure for the preparation of 5-diaminomethylenebarbiturates (DABA) was developed. This procedure is very simple and applicable to the preparation of large quantities of DABA derivatives. Through an X-ray structural study of one of the DABA derivatives, it was established that these compounds have an ylide-type structure with strong charge separation within the molecule. |
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| Keywords: | barbituric acid 5-diaminomethylenebarbiturates immuno-modulating agents |
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