Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine |
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| Authors: | Tohru HoriguchiTakayuki Oritani Hiromasa Kiyota |
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| Institution: | Division of Life Science, Graduate School of Agricultural Science, Tohoku University, 1-1, Tsutsumidori-Amamiya, Aoba, Sendai, Miyagi 9818555, Japan |
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| Abstract: | 2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated. |
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| Keywords: | taxol antitumor activity taxinine m-azidobenzoyl |
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