Derivatives of 5-(Dimethylamino)-4-tosyl-1,3-oxazole-2-carbaldehyde and Its Analogs |
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Authors: | R. N. Vyzhdak A. A. Danielova V. V. Kiselev B. S. Drach |
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Affiliation: | (1) Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine;(2) Ukrainian State University of Chemical Technology, Dnepropetrovsk, Russia |
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Abstract: | Treatment of N-(2,2,2-trichloro-1-tosylethyl)dichloroacetamide with excess dimethylamine, piperidine, or morpholine gave substituted aminals of the oxazole series, whose facile acid hydrolysis provided 5-(dimethylamino)-4-tosyl-1,3-oxazol-2-carbaldehyde and its analogs having the piperidino and morpholino group in the 5 position of the oxazole ring. The resulting aldehydes and their aminals were condensed with phenylhydrazine, thiosemicarbazide, N-alkylrhodanines, and 1,3-dimethylbarbituric acid to obtain 2,5-disubstituted derivatives of 4-tosyl-1,3-oxazole.__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 6, 2005, pp. 1002–1006.Original Russian Text Copyright © 2005 by Vyzhdak, Danielova, Kiselev, Drach. |
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