Synthesis,characterization, antifungal,antibacterial, and antitumor activities of some tris(pentafluorophenyl)arsenic(V) derivatives

A series of tris(pentafluorophenyl) arsenic(V) derivatives of the type (C₆F₅)₃AsL₂, (C₆F₅)₃As(Cl)(L) L = ? OCOC₆H₄(o‐OH), ? OCOC‐(OH)(C₆H₅)₂, and 2‐(6‐OCH₃C₁₀H₆)CH(CH₃) COO? ], and cycloarsenates, (R = C₆H₅, p‐CF₃C₆H₄, and p‐OCH₃C₆H₄) have been isolated and characterized by elemental analysis and spectroscopic data (infrared; ¹H, ¹⁹F, and ¹³C NMR). These compounds were screened for their in vitro antifungal, antibacterial, and antitumor activities and were found to show moderate to significant activity. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:181–187, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20593