Synthesis,structure, and antibacterial evaluation of new N‐substituted‐3‐amino‐ 5‐oxo‐4‐phenyl‐2,5‐dihydro‐1H‐pyrazole‐1‐carbothioamides |
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| Authors: | Monika Pitucha Liliana Mazur Urszula Kosikowska Anna Pachuta‐Stec Anna Malm &#x;ukasz Popio&#x;ek Zofia Rza&#x;czy&#x;ska |
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| Abstract: | Novel N‐substituted‐3‐amino‐5‐oxo‐4‐phenyl‐2,5‐dihydro‐1H‐pyrazole‐1‐carbothioamide derivatives were synthesized by means of two methods. First is the cyclization reaction of 1‐(cyanophenyl)acetyl‐4‐substituted thiosemicarbazide, and the second one is reaction of cyanophenyl acetic acid hydrazide with isothiocyanate. Structures of new compounds were confirmed by elemental analysis, 1H NMR, and X‐ray diffraction analysis. Biological evaluation showed that some of them possess promising antibacterial activities. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:215–221, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20598 |
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