A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
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| Authors: | Yang Li Cai-Lin Zhang Wei-Heng Huang Ning Sun Meng Hao Helfried Neumann Matthias Beller |
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| Institution: | Xi''an Key Laboratory of Textile Chemical Engineering Auxiliaries, School of Environmental and Chemical Engineering, Xi''an Polytechnic University, No. 19 Jinhua South Road, 710048 Xi''an China.; Leibniz-Institut für Katalyse e.V., RostockAlbert-Einstein-Straße 29a, 18059 Rostock Germany, |
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| Abstract: | β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields.β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. |
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