Study of DNA Light Switch Ru(II) Complexes : Synthesis,Characterization, Photocleavage and Antimicrobial Activity |
| |
| Authors: | Praveen Kumar Yata M. Shilpa P. Nagababu M. Rajender Reddy Laxma Reddy Kotha Nazar Md Gabra S. Satyanarayana |
| |
| Affiliation: | 1.Department of Chemistry,Osmania University,Hyderabad,India;2.Institute of Chemistry,Academia Sinica,Nankang,Taipei;3.Instituto de Tecnologia Química e Biológica (ITQB) Universidade Nova de Lisboa Av. da República,Oeiras,Portugal |
| |
| Abstract: | The three Ru(II) complexes of [Ru(phen)2dppca]2+ (1) [Ru(bpy)2dppca]2+ (2) and [Ru(dmb)2dppca]2+ (3) (where phen = 1,10 phenanthroline, bpy = 2,2-bipyridine, dmb = 2 ,2-dimethyl 2′,2′-bipyridine and polypyridyl ligand containing a single carboxylate functionality dppca ligand (dipyridophenazine-11-carboxylic acid) have been synthesized and characterized. These complexes have been shown to act as promising calf thymus DNA intercalators and a new class of DNA light switches, as evidenced by UV-visible and luminescence titrations with Co2+ and EDTA, steady-state emission quenching by [Fe(CN)6]4− and KI, DNA competitive binding with ethidium bromide, viscosity measurements, and DNA melting experiments. The results suggest that 1, 2, and 3 complexes bind to CT-DNA through intercalation and follows the order 1 > 2 > 3. Under irradiation at 365 nm, the three complexes have also been found to promote the photocleavage of plasmid pBR322 DNA. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
