2,6-Dihydroxy-4,5-dihydropyrimidine derivatives

Alkylamides of DL-4,5-dihydroorotic acid were synthesized by catalytic hydrogenation (5% Rh on Al₂O₃). The reaction of the n-butyl ester of DL-4,5-dihydroorotic acid with alkylamines and hydrazine gave N,N-dialkylamides, the dihydrazide of DL-ureidosuccinic acid, and the hydrazide of DL-4,5-dihydroorotic acid. The products of the condensation of the latter with aromatic aldehydes were obtained.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 105–108, January, 1972.