The Gewald multicomponent reaction |
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| Authors: | Yijun Huang Alexander Dömling |
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| Affiliation: | (1) Department of Applied Chemistry, Laboratory of Combinatorial Drug Discovery, National Chiao Tung University, Hsinchu, 300-10, Taiwan; |
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| Abstract: | The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products. |
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