|
|||||
|
|
Instability of mercury in specimens of human urine for external quality assessment |
|
| Authors: | Andrew Taylor Robert L Jones Alain Leblanc Olav Mazarrasa Mi-Young Lee Patrick J Parsons Marina Patriarca Jean-Philippe Weber Cas Weykamp |
| Institution: | 1. Centre for Clinical Science and Measurement, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK 2. Nutritional Biochemistry, Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA, 30341-3724, USA 3. Centre de Toxicologie, Institut National de Santé Publique du Québec, 945 Wolfe Avenue, Saint-Foy, QC, G1V 5B3, Canada 4. Laboratorio de Higiene Industrial, Centro de Seguridad y Salud en el Trabajo, Gobierno de Cantabria, 39012, Santander, Spain 5. Occupational Safety and Health Research Institute, #34-4 Gusan-Dong, Bupyong-gu, Incheon, 403-711, Republic of Korea 6. New York State Department of Health, Wadsworth Center, PO Box 509, Albany, NY, 12201-0509, USA 7. Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, 00161, Rome, Italy 8. MCA Laboratory, Queen Beatrix Hospital, 7101 BN, Winterswijk, The Netherlands |
| Abstract: | An under-recovery of inorganic mercury added to urine and a wide range of results is observed in quality assessment schemes (EQAS) for trace elements. Furthermore, the under-recoveries are inconsistent suggesting features associated with the urine matrix may make the mercury unavailable for measurement. To investigate the instability of mercury in urine the following experiments were set up: (1) a sample of Hg2+ in water with various ‘stabilizers’ added was sent to UK external quality assessment scheme participants. (2) Urine was collected from volunteers who also completed a 3-day food diary. Hg, Ca, Mg, Se, uric acid, phosphate, creatinine, reducing substances and protein were measured. Inorganic mercury was spiked into the urine, stabilizers were added and the mercury determined following storage. The results confirmed under-recovery of mercury in association with the urine matrix. Further investigations of how urinary components affect the measurement of mercury are necessary. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |