Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects |
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Authors: | Ratnakar S James Woods Mark Lubag Angelo J M Kovacs Zoltan Sherry A Dean |
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Institution: | Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. |
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Abstract: | The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F approximately CO2tBu < CN < H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction. |
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