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Stereocontrolled synthesis of 7-hydroxy- and 7-acetoxy-PGI2: New stable PGI2 analogues
Authors:Kiyoshi Bannai  Takeshi Toru  Takeo Ba  Toshio Tanaka  Noriaki Okamura  Kenzo Watanabe  Seizi Kurozumi
Affiliation:Teijin Institute for Bio-Medical Research Hino, Tokyo 191, Japan
Abstract:Stable analogues of PGI2, 7-hydroxy- and 7-acetoxy-PGI2, were synthesized from protected PGI2 methyl ester 1bvia sulfoxides 6a, 6b through stereocontrolled sulfoxide-sulfenate rearrangement.
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