Optically active N-hydroxytartrimides for enantioselective peptide synthesis |
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| Authors: | Takero Teramoto Mikito Deguchi Toshikazu Kurosaki Makoto Okawara |
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| Affiliation: | Department of Industrial Chemistry, Tokyo Institute of Polytechnics, Iiyama, Atsugi 243-02, Japan;Research Laboratory of Resources Utilization, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 227, Japan |
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| Abstract: | Preparations of optically active N-hydroxytartrimides were achieved. 1,3,4-Trihydroxysuccinimide ester of Z-L-alanine and 1-hydroxy-3,4-diacetoxysuccinimide ester of Z-D-alanine were allowed to react with D,L-alaninate to produce L-L form and D-D form of Z-Ala-Ala-OEt respectively (optical yield 100%). |
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