Novel ring transformation reactions of xanthine derivatives |
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| Authors: | Mikio Hori Tadashi Kataoka Hiroshi Shimizu Eiji Imai Yukiharu Matsumoto Iwao Miura |
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| Institution: | Gifu College of Pharmacy, 5-6-1, Mitahora-higashi, Gifu 502, Japan;Laboratories of Natural Products Chemistry, Otsuka Pharmaceutical Co. Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-01, Japan |
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| Abstract: | The novel ring transformation reactions were found in the reactions of 1,3,7,9-tetra-alkyl-8,9-dihydroxanthines and acetylenic compounds. The reaction of the dihydroxanthine with DMAD gave a propellane type compound and with methyl propiolate afforded the similar type compound and a pyrimido4,5-b]diazepine derivative. The mechanism of these reactions was also discussed. |
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