Heterocyclic Syntheses on the Basis of Arylation Products of Unsaturated Compounds: X. 3-Aryl-2-chloropropanals as Reagents for the Synthesis of 2-Amino-1,3-thiazole Derivatives |
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| Authors: | Obushak N D Matiichuk V S Vasylyshin R Ya Ostapyuk Yu V |
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| Institution: | (1) Ivan Franko Lviv National University, ul. Kirilla i Mefodiya 6, Lviv, 79005, Ukraine |
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| Abstract: | Meerwein reaction of arenediazonium chlorides with acrolein gave 3-aryl-2-chloropropanals which were brought into cyclocondensation with thiourea. The resulting 2-amino-5-benzyl-1,3-thiazoles were acylated with carboxylic acid chlorides and phthalic anhydride to afford, respectively, 2-acylamino-5-benzyl-1,3-thiazoles and N-(5-benzyl-1,3-thiazol-2-yl)phthalimides. |
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