Highly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery |
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Authors: | Patil Kiran M Naik Rangeetha J Rajpal Fernandes Moneesha Ganguli Munia Kumar Vaijayanti A |
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Institution: | Organic Chemistry Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India. |
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Abstract: | The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)(4) or (r-ahx-r-r-apr-r)(2) increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells. |
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