Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates |
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| Authors: | Sävmarker Jonas Rydfjord Jonas Gising Johan Odell Luke R Larhed Mats |
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| Affiliation: | Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden. |
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| Abstract: | A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2'-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields. |
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