Electrophilic trifluoromethylation by copper-catalyzed addition of CF3-transfer reagents to alkenes and alkynes |
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Authors: | Janson Pär G Ghoneim Ibrahim Ilchenko Nadia O Szabó Kálmán J |
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Affiliation: | Department of Organic Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. |
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Abstract: | Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of CuI, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction. |
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