Ultrasensitive bioelectronic devices based on conducting polymers for electrophysiology studies |
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Authors: | Sanaz Asgarifar Pedro M. C. Inácio Ana L. G. Mestre Henrique Leonel Gomes |
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Affiliation: | 1.Faculdade de Ciências e Tecnologia,Universidade do Algarve,Faro,Portugal;2.Instituto de Telecomunica??es,Lisbon,Portugal |
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Abstract: | Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene doped with poly(styrenesulfonate) (PEDOT:PSS) are evaluated as transducers to record extracellular signals in cell populations. The performance of the polymer electrode is compared with a gold electrode. A small-signal impedance analysis shows that in the presence of an electrolyte, the polymer electrode establishes for frequencies below 100 Hz a higher capacitive electrical double layer at the electrode/electrolyte interface. Furthermore, the polymer/electrolyte interfacial resistance is several orders of magnitude lower than the resistance of the gold/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. The ultra-sensitivity of the polymer-based transducer system was demonstrated by recording the electrical activity of cancer cells of the nervous system. |
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