Interface functional architecture using mixed thiol monolayers: Effect of the composition and spatial organization on the immobilization of low-molecular-weight ligands |
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| Authors: | B. A. Snopok P. N. Boltovets F. J. Rowell |
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| Affiliation: | (1) V. E. Lashkarev Institute of Semiconductor Conductors, National Academy of Sciences of Ukraine, Prospekt Nauky, 41, Kyiv, 03028, Ukraine;(2) School of Health, Natural and Social Sciences, University of Sunderland, Fleming Building, Wharncliffe Street, Sunderland, SR 1 3SD, UK |
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| Abstract: | A simple procedure is examined for forming a selective sensor coating using mixed self-assembling thiol monolayers functionalized by molecules of the sulfanilamide antibiotic, sulfamethoxazol (SMX). A model is proposed for the interface processes, which accounts for the complex dependence of the adsorption capacity of the coatings obtained on the surface density of the reactive groups and the low adsorption capacity at high reaction site concentrations. The model was supported by competitive inhibition analysis. __________ Translated from Teoreticheskaya i éksperimental’naya Khimiya, Vol. 44, No. 3, pp. 158–164, May–June, 2008. |
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| Keywords: | mixed monolayers immobilization density biosensors surface plasmon resonance microscopy of atomic forces sulfamethoxazol |
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