| Syntheses of Two Potential Ligands for Tc-99m Labeling as Diagnosis Agents of Alzheimer's Disease |
| |
| 作者姓名： | 庄治平 孔一田美萍 小野正博 侯元淳 孔繁渊 |
| |
| 作者单位： | Department of Radiology，Universisy of Pennsylvania，Room 305，3700 Market Street，Philadelphia，Pennsylvania，19104，USA，Department of Radiology，Universisy of Pennsylvania，Room 305，3700 Market Street，Philadelphia，Pennsylvania，19104，USA，Department of Radiology，Universisy of Pennsylvania，Room 305，3700 Market Street，Philadelphia，Pennsylvania，19104，USA，Department of Radiology，Universisy of Pennsylvania，Room 305，3700 Market Street，Philadelphia，Pennsylvania，19104，USA，Department of Pharmacology，University of Pennsylvania，Room 305，3700 Market Street，Philadelphia，Pennsylvania，19104，USA |
| |
| 基金项目： | Project supported by the National Institute of Health(NIH)USA and the Institute for the Study of Aging(ISOA)USA. |
| |
| 摘 要： | Two types of ligands-biphenyl and stilbene derivatives, whichcan be labeled with Tc-99m for the diagnosis of Alzheimer'sdisease (AD) have been synthesized successfully. The key stepsin these two syntheses involved Suzuki reaction and Wittig reac-tion respectively. The new discovered debromination reactionmay be expanded to the compounds with double or triple bondadjacent to the carbon atom bearing the bromine atoms. Thesetypes of syntheses provide a route to a series of biphenyl andstilbene derivatives that will benefit the search of new imagingagents for AD.
|
Syntheses of Two Potential Ligands for Tc-99m Labeling as Diagno-sis Agents of Alzheimer's Disease |
| |
| ZHUANG,Zhi-Ping KUNG,Mei-Ping ONO,Masahiro
HOU,Catherine KUNG,Hank F.Syntheses of Two Potential Ligands for Tc-99m Labeling as Diagnosis Agents of Alzheimer''''s Disease[J].Chinese Journal of Chemistry,2003(7). |
| |
| Authors: | ZHUANG Zhi-Ping KUNG Mei-Ping ONO Masahiro
HOU Catherine KUNG Hank F |
| |
| Institution: | ZHUANG,Zhi-Ping KUNG,Mei-Ping ONO,Masahiro
HOU,Catherine KUNG,Hank F
Department of Radiology,University of Pennsylvania,Room 305,3700 Market Street,Philadelphia,Pennsylvania,19104,USA Department of Pharmacology,University of Pennsylvania,Room 305,3700 Market Street,Philadelphia,Pennsylvania,19104,USA |
| |
| Abstract: | Two types of ligands-biphenyl and stilbene derivatives, -which can be labeled with Tc-99m for the diagnosis of Alzheimer' s disease (AD) have been synthesized successfully. The key steps in these two syntheses involved Suzuki reaction and Wittig reaction respectively. The new discovered debromination reaction may be expanded to the compounds with double or triple bond adjacent to the carbon atom bearing the bromine atoms. These types of syntheses provide a route to a series of biphenyl and stilbene derivatives that will benefit the search of new imaging agents for AD. |
| |
| Keywords: | Alzheimer' s disease imaging agent diagnosis biphenyl stilbene Suzuki reaction Wittig reaction |
| 本文献已被 CNKI 等数据库收录！ |
