Intercalation of PM-19 into and in vitro Release of Anti-tumor Drug from Layered Double Hydroxide

Introduction Recently, controlled release of drugs and gene delivery technology have received considerable attention due to their numerous advantages including prolonged duration of action of an active agent, improved efficacy, reduced toxicity and convenience compared to the conventional dosage forms1]. In this field typical systems are polymer delivery systems depending on the hydrolysis-induced degradation, swelling and erosion of carriers′ structures1, 2], mesoporous silica carrier systems relying on capturing and releasing the CdS nanoparticles3], and layered materials release systems based on ion-exchange principle4].