Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions |
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| Authors: | Banfi Luca Guanti Andrea Basso Giuseppe Lecinska Paulina Riva Renata |
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| Affiliation: | Department of Chemistry and Industrial Chemistry, via Dode- caneso 31, 16146, Genova, Italy. banfi@chimica.unige.it |
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| Abstract: | Various dihydrobenzo[f][1,4]oxazepin-5-ones have been convergently prepared in 2-3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 steps); in the second one an intermolecular Mitsunobu reaction was followed by a deprotection step and then by an intramolecular Ugi reaction. Also a "convertible" isocyanide was used. |
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