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A direct method for the substitution of imidazo[1,5-a]pyridines at position 5 |
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| Authors: | Philip Blatcher David Middlemiss |
| Institution: | Chemistry Division, Glaxo Group Research Ltd., Ware, Herts. SG12 0DJ U.K. |
| Abstract: | 3-Ethylthioimidazo1,5-a]pyridine lithiates at carbon 5. Quenching of the anion with an electrophile followed by desulphurisation gives 5-substituted imidazo1,5-a]pyridines. |
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