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β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group |
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| Authors: | Bruce H. Lipshutz Joseph J. Pegram |
| Affiliation: | Department of Chemistry University of California at Santa Barbara Santa Barbara, CA 93106 U.S.A. |
| Abstract: | Reactions of β-(trimethylsilyl)ethoxymethyl chloride with alcohols afford the corresponding ethers in high yield. Deprotection using n-Bu4NF in THF or HMPA cleanly regenerates the hydroxyl function. |
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