Substituent directive effects in 1,2-benzodiazepine synthesis via electrocyclic aromatic substitution by the diazo-group: a rearrangement of 9- to 7-substituted 3H-1,2-benzodiazepines |
| |
| Authors: | Thomas K Miller John T Sharp H Raj Sood Edward Stefaniuk |
| |
| Institution: | Department of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ UK |
| |
| Abstract: | The directive effect of aryl-substituents on the site of ring closure in the electrocyclisation of 1-aryl-3-diazoalkenes has been investigated. At 80°C the product ratio is determined by kinetic control but for some substituents the kinetically favoured 9-substituted 3-1,2-benzodiazepines undergo a new rearrangement to their more stable 7-substituted isomers. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
