Synthesis of (±)-negamycin and of (±)-epinegamycin |
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| Authors: | Georges Pasquet Dominique Boucherot William R Pilgrim Brian Wright |
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| Institution: | Centre de Recherches, I.C.I. Pharma, Z.I.S.E. B.P. 401, 51064 Reims, France;Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, S010 4TG, United Kingdom |
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| Abstract: | The antibiotic negamycin and its diastereomer have both been synthesized in racemic form. The latter has been found to possess antibacterial activity, but at a lower level than negamycin itself. |
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